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Overview

TCTC

Chronic viral hepatitis B and C, and related liver diseases (liver cirrhosis and hepatocellular carcinoma) are still major health problems in Asian Pacific region. After controlling chronic viral hepatitis, nonalcoholic fatty liver diseases (NAFLD) and drug-induced liver injury (DILI) will become next most common etiologies within liver diseases. The purpose of Taiwan Liver Diseases Consortium (TLC) is to solve these devastating health problems through the conduction of clinical studies with high quality.

Strengths

TCTC

  1. Solve devastating liver diseases through investigator-initiated trials and early phase trials.
  2. Investigate new treatment for chronic viral hepatitis B.
  3. Investigate new treatment for hepatocellular carcinoma.
  4. Identify biomarkers for treatment response and clinical outcomes.
  5. Study prevalence and prevention of fatty liver and drug-induced liver injury

Major Achievements

TCTC

Main findings
  1. LDV/SOF for 12 weeks achieved 100% SVR12 rate in patients with HBV and HCV GT 1 or 2 infection; well tolerated.
  2. Treatment with LDV/SOF for 12 weeks was associated with high rate of HBV viral reactivation: 71% of patients (79/111).
  3. Safety monitoring in HBsAg positive HBV-HCV coinfected patients is warranted beyond Wk 12.
  4. 5 patients (5/111, 5%) lost HBsAg during the post treatment period, which was novel.
We clarified part of the black box regarding the FDA warning of HBV reactivation in CHC patients receiving DAAs (Sept. 2016). Our data will help develop strategies for monitoring and prevention of reactivation.
Liu CJ et al, Gastroenterology 2018 March.

Members

TCTC

National Taiwan University Hospital

Taichung Veterans General Hospital

National Taiwan University Graduate Institute of Clinical Medicine

National Taiwan University Hospital

Mackay Memorial Hospital, Taipei Branch

China Medical University Hospital, Taichung

Taipei Veterans General Hospital

Linkou Chang Gung Memorial Hospital

Kaohsiung Medical University Hospital

National Taiwan University Hospital

Taipei City Hospital Renai Branch

Cathay General Hospital

National Taiwan University Hospital

Chia-Yi Christian Hospital

Kaohsiung Chang Gung Memorial Hospital

Taipei Veterans General Hospital

National Taiwan University Hospital

Taipei City Hospital Renai Branch

National Taiwan University Hospital

National Taiwan University Hospital

National Taiwan University Hospital

Cheng-Kong University Hospital

Mackay Memorial Hospital, Taitung Branch

Taipei Tzu Chi General Hospital

Taipei Veterans General Hospital

Linkou Chang Gung Memorial Hospital

Kaohsiung Medical University Hospital